Challenges of evaluating and modelling vaccination in emerging infectious diseases
Madewell, Zachary J.; Dean, Natalie E.; Berlin, Jesse A.; Coplan, Paul M.; Davis, Kourtney J.; Struchinerf, Claudio J.; Halloran, M. Elizabeth
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Resumo
Outbreaks of emerging pathogens pose unique methodological and practical challenges for the design, implementation, and evaluation of vaccine efficacy trials. Lessons learned from COVID-19 highlight the need for innovative and flexible study design and application to quickly identify promising candidate vaccines. Trial design strategies should be tailored to the dynamics of the specific pathogen, location of the outbreak, and vaccine prototypes, within the regional socioeconomic constraints. Mathematical and statistical models can assist investigators in designing infectious disease clinical trials. We introduce key challenges for planning, evaluating, and modelling vaccine efficacy trials for emerging pathogens.
Ficha do documento
- Tipo
- Artigo científico
- Ano
- 2021
- Instituição
- Fundação Getulio Vargas
- Fonte
- Repositório da FGV
- Idioma
- Português
- Acesso
- Não informado
- Identificador
- oai:repositorio.fgv.br:10438/33772
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